Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.
Identifieur interne : 001072 ( Main/Exploration ); précédent : 001071; suivant : 001073Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.
Auteurs : Ruth Ladenstein [Autriche] ; Ulrike Pötschger [Autriche] ; Andrew D J. Pearson [Royaume-Uni] ; Penelope Brock [Royaume-Uni] ; Roberto Luksch [Italie] ; Victoria Castel [Espagne] ; Isaac Yaniv [Israël] ; Vassilios Papadakis [Grèce] ; Geneviève Laureys [Belgique] ; Josef Malis [République tchèque] ; Walentyna Balwierz [Pologne] ; Ellen Ruud [Norvège] ; Per Kogner [Suède] ; Henrik Schroeder [Danemark] ; Ana Forjaz De Lacerda [Portugal] ; Maja Beck-Popovic [Suisse] ; Pavel Bician [Slovaquie] ; Mikl S Garami [Hongrie] ; Toby Trahair [Australie] ; Adela Canete [Espagne] ; Peter F. Ambros [Autriche] ; Keith Holmes [Royaume-Uni] ; Mark Gaze [Royaume-Uni] ; Günter Schreier [Autriche] ; Alberto Garaventa [Italie] ; Gilles Vassal [France] ; Jean Michon [France] ; Dominique Valteau-Couanet [France]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Agences internationales, Busulfan (administration et posologie), Carboplatine (administration et posologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Melphalan (administration et posologie), Mâle, Métastase lymphatique, Neuroblastome (anatomopathologie), Neuroblastome (traitement médicamenteux), Nourrisson, Pronostic, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Stade de la tumeur, Taux de survie, Tumeurs osseuses (secondaire), Tumeurs osseuses (traitement médicamenteux), Étoposide (administration et posologie), Études de suivi.
- MESH :
- administration et posologie : Busulfan, Carboplatine, Melphalan, Étoposide.
- anatomopathologie : Neuroblastome.
- secondaire : Tumeurs osseuses.
- traitement médicamenteux : Neuroblastome, Tumeurs osseuses.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adolescent, Adulte, Agences internationales, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Métastase lymphatique, Nourrisson, Pronostic, Stade de la tumeur, Taux de survie, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Bone Neoplasms (drug therapy), Bone Neoplasms (secondary), Busulfan (administration & dosage), Carboplatin (administration & dosage), Child, Child, Preschool, Etoposide (administration & dosage), Female, Follow-Up Studies, Humans, Infant, International Agencies, Lymphatic Metastasis, Male, Melphalan (administration & dosage), Neoplasm Staging, Neuroblastoma (drug therapy), Neuroblastoma (pathology), Prognosis, Survival Rate, Young Adult.
- MESH :
- chemical , administration & dosage : Busulfan, Carboplatin, Etoposide, Melphalan.
- drug therapy : Bone Neoplasms, Neuroblastoma.
- pathology : Neuroblastoma.
- secondary : Bone Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adolescent, Adult, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, International Agencies, Lymphatic Metastasis, Male, Neoplasm Staging, Prognosis, Survival Rate, Young Adult.
Abstract
High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however, which regimen has the greatest patient benefit has not been established. We aimed to assess event-free survival after high-dose chemotherapy with busulfan and melphalan compared with carboplatin, etoposide, and melphalan.
DOI: 10.1016/S1470-2045(17)30070-0
PubMed: 28259608
Affiliations:
- Australie, Autriche, Belgique, Danemark, Espagne, France, Grèce, Hongrie, Israël, Italie, Norvège, Pologne, Portugal, Royaume-Uni, République tchèque, Slovaquie, Suisse, Suède
- Angleterre, Attique (région), Bohême centrale, Canton de Vaud, Grand Londres, Hongrie centrale, Lombardie, Svealand, Vienne (Autriche), Île-de-France, Østlandet
- Athènes, Budapest, Lausanne, Londres, Milan, Oslo, Paris, Prague, Stockholm, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Electronic address: ruth.ladenstein@ccri.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna, Austria; St Anna Children's Hospital and Department of Paediatrics of the Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Potschger, Ulrike" sort="Potschger, Ulrike" uniqKey="Potschger U" first="Ulrike" last="Pötschger">Ulrike Pötschger</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pearson, Andrew D J" sort="Pearson, Andrew D J" uniqKey="Pearson A" first="Andrew D J" last="Pearson">Andrew D J. Pearson</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric and Adolescent Drug Development Team, Oak Centre for Children and Young People, Institute of Cancer Research, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric and Adolescent Drug Development Team, Oak Centre for Children and Young People, Institute of Cancer Research, Royal Marsden Hospital, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Brock, Penelope" sort="Brock, Penelope" uniqKey="Brock P" first="Penelope" last="Brock">Penelope Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department Paediatric Oncology, Great Ormond Street Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department Paediatric Oncology, Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Luksch, Roberto" sort="Luksch, Roberto" uniqKey="Luksch R" first="Roberto" last="Luksch">Roberto Luksch</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Ematologia e Onco-ematologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Ematologia e Onco-ematologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name><affiliation wicri:level="1"><nlm:affiliation>Sackler Faculty of Medicine, Tel Aviv University, Schneider Children's Medical Center of Israel, Petach, Tikvah, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler Faculty of Medicine, Tel Aviv University, Schneider Children's Medical Center of Israel, Petach, Tikvah</wicri:regionArea><wicri:noRegion>Tikvah</wicri:noRegion></affiliation></author><author><name sortKey="Papadakis, Vassilios" sort="Papadakis, Vassilios" uniqKey="Papadakis V" first="Vassilios" last="Papadakis">Vassilios Papadakis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Paediatric Haematology-Oncology, Agia Sofia Children's Hospital Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Paediatric Haematology-Oncology, Agia Sofia Children's Hospital Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Laureys, Genevieve" sort="Laureys, Genevieve" uniqKey="Laureys G" first="Geneviève" last="Laureys">Geneviève Laureys</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Malis, Josef" sort="Malis, Josef" uniqKey="Malis J" first="Josef" last="Malis">Josef Malis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Balwierz, Walentyna" sort="Balwierz, Walentyna" uniqKey="Balwierz W" first="Walentyna" last="Balwierz">Walentyna Balwierz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Ruud, Ellen" sort="Ruud, Ellen" uniqKey="Ruud E" first="Ellen" last="Ruud">Ellen Ruud</name><affiliation wicri:level="3"><nlm:affiliation>Department of Paediatric Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Paediatric Medicine, Rikshospitalet, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kogner, Per" sort="Kogner, Per" uniqKey="Kogner P" first="Per" last="Kogner">Per Kogner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Schroeder, Henrik" sort="Schroeder, Henrik" uniqKey="Schroeder H" first="Henrik" last="Schroeder">Henrik Schroeder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="De Lacerda, Ana Forjaz" sort="De Lacerda, Ana Forjaz" uniqKey="De Lacerda A" first="Ana Forjaz" last="De Lacerda">Ana Forjaz De Lacerda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatric and Adolescent Oncology, Portuguese Institute of Oncology, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Paediatric and Adolescent Oncology, Portuguese Institute of Oncology, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Beck Popovic, Maja" sort="Beck Popovic, Maja" uniqKey="Beck Popovic M" first="Maja" last="Beck-Popovic">Maja Beck-Popovic</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics and Pediatric Surgery, Pediatric Haematology Oncology Unit, University Hospital Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pediatrics and Pediatric Surgery, Pediatric Haematology Oncology Unit, University Hospital Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bician, Pavel" sort="Bician, Pavel" uniqKey="Bician P" first="Pavel" last="Bician">Pavel Bician</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Pediatric Oncology and Hematology, University Children's Hospital, Banska Bystrica, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Clinic of Pediatric Oncology and Hematology, University Children's Hospital, Banska Bystrica</wicri:regionArea><wicri:noRegion>Banska Bystrica</wicri:noRegion></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation wicri:level="3"><nlm:affiliation>Second Department of Pediatrics, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Trahair, Toby" sort="Trahair, Toby" uniqKey="Trahair T" first="Toby" last="Trahair">Toby Trahair</name><affiliation wicri:level="1"><nlm:affiliation>Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Canete, Adela" sort="Canete, Adela" uniqKey="Canete A" first="Adela" last="Canete">Adela Canete</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Ambros, Peter F" sort="Ambros, Peter F" uniqKey="Ambros P" first="Peter F" last="Ambros">Peter F. Ambros</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute Department of Tumour Biology, Medical University, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute Department of Tumour Biology, Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Holmes, Keith" sort="Holmes, Keith" uniqKey="Holmes K" first="Keith" last="Holmes">Keith Holmes</name><affiliation wicri:level="3"><nlm:affiliation>Department Paediatric Surgery, St Georges Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department Paediatric Surgery, St Georges Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gaze, Mark" sort="Gaze, Mark" uniqKey="Gaze M" first="Mark" last="Gaze">Mark Gaze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University College Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schreier, Gunter" sort="Schreier, Gunter" uniqKey="Schreier G" first="Günter" last="Schreier">Günter Schreier</name><affiliation wicri:level="1"><nlm:affiliation>Center for Health and Bioresources, AIT Austrian Institute of Technology, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Center for Health and Bioresources, AIT Austrian Institute of Technology, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Garaventa, Alberto" sort="Garaventa, Alberto" uniqKey="Garaventa A" first="Alberto" last="Garaventa">Alberto Garaventa</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Unit, Istituto Giannina Gaslini, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Unit, Istituto Giannina Gaslini, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Vassal, Gilles" sort="Vassal, Gilles" uniqKey="Vassal G" first="Gilles" last="Vassal">Gilles Vassal</name><affiliation wicri:level="3"><nlm:affiliation>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michon, Jean" sort="Michon, Jean" uniqKey="Michon J" first="Jean" last="Michon">Jean Michon</name><affiliation wicri:level="3"><nlm:affiliation>Children, Adolescent and Young Adults Department, Institut Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children, Adolescent and Young Adults Department, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Valteau Couanet, Dominique" sort="Valteau Couanet, Dominique" uniqKey="Valteau Couanet D" first="Dominique" last="Valteau-Couanet">Dominique Valteau-Couanet</name><affiliation wicri:level="3"><nlm:affiliation>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28259608</idno><idno type="pmid">28259608</idno><idno type="doi">10.1016/S1470-2045(17)30070-0</idno><idno type="wicri:Area/PubMed/Corpus">000E64</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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first="Ruth" last="Ladenstein">Ruth Ladenstein</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna, Austria; St Anna Children's Hospital and Department of Paediatrics of the Medical University, Vienna, Austria. Electronic address: ruth.ladenstein@ccri.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna, Austria; St Anna Children's Hospital and Department of Paediatrics of the Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Potschger, Ulrike" sort="Potschger, Ulrike" uniqKey="Potschger U" first="Ulrike" last="Pötschger">Ulrike Pötschger</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute (CCRI)-S(2)IRP: Studies and Statistics for Integrated Research and Projects, Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pearson, Andrew D J" sort="Pearson, Andrew D J" uniqKey="Pearson A" first="Andrew D J" last="Pearson">Andrew D J. Pearson</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric and Adolescent Drug Development Team, Oak Centre for Children and Young People, Institute of Cancer Research, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric and Adolescent Drug Development Team, Oak Centre for Children and Young People, Institute of Cancer Research, Royal Marsden Hospital, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Brock, Penelope" sort="Brock, Penelope" uniqKey="Brock P" first="Penelope" last="Brock">Penelope Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department Paediatric Oncology, Great Ormond Street Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department Paediatric Oncology, Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Luksch, Roberto" sort="Luksch, Roberto" uniqKey="Luksch R" first="Roberto" last="Luksch">Roberto Luksch</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Ematologia e Onco-ematologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Ematologia e Onco-ematologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name><affiliation wicri:level="1"><nlm:affiliation>Sackler Faculty of Medicine, Tel Aviv University, Schneider Children's Medical Center of Israel, Petach, Tikvah, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler Faculty of Medicine, Tel Aviv University, Schneider Children's Medical Center of Israel, Petach, Tikvah</wicri:regionArea><wicri:noRegion>Tikvah</wicri:noRegion></affiliation></author><author><name sortKey="Papadakis, Vassilios" sort="Papadakis, Vassilios" uniqKey="Papadakis V" first="Vassilios" last="Papadakis">Vassilios Papadakis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Paediatric Haematology-Oncology, Agia Sofia Children's Hospital Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Paediatric Haematology-Oncology, Agia Sofia Children's Hospital Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Laureys, Genevieve" sort="Laureys, Genevieve" uniqKey="Laureys G" first="Geneviève" last="Laureys">Geneviève Laureys</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Malis, Josef" sort="Malis, Josef" uniqKey="Malis J" first="Josef" last="Malis">Josef Malis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Balwierz, Walentyna" sort="Balwierz, Walentyna" uniqKey="Balwierz W" first="Walentyna" last="Balwierz">Walentyna Balwierz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Ruud, Ellen" sort="Ruud, Ellen" uniqKey="Ruud E" first="Ellen" last="Ruud">Ellen Ruud</name><affiliation wicri:level="3"><nlm:affiliation>Department of Paediatric Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Paediatric Medicine, Rikshospitalet, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kogner, Per" sort="Kogner, Per" uniqKey="Kogner P" first="Per" last="Kogner">Per Kogner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Schroeder, Henrik" sort="Schroeder, Henrik" uniqKey="Schroeder H" first="Henrik" last="Schroeder">Henrik Schroeder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="De Lacerda, Ana Forjaz" sort="De Lacerda, Ana Forjaz" uniqKey="De Lacerda A" first="Ana Forjaz" last="De Lacerda">Ana Forjaz De Lacerda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatric and Adolescent Oncology, Portuguese Institute of Oncology, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Paediatric and Adolescent Oncology, Portuguese Institute of Oncology, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Beck Popovic, Maja" sort="Beck Popovic, Maja" uniqKey="Beck Popovic M" first="Maja" last="Beck-Popovic">Maja Beck-Popovic</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics and Pediatric Surgery, Pediatric Haematology Oncology Unit, University Hospital Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pediatrics and Pediatric Surgery, Pediatric Haematology Oncology Unit, University Hospital Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bician, Pavel" sort="Bician, Pavel" uniqKey="Bician P" first="Pavel" last="Bician">Pavel Bician</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Pediatric Oncology and Hematology, University Children's Hospital, Banska Bystrica, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Clinic of Pediatric Oncology and Hematology, University Children's Hospital, Banska Bystrica</wicri:regionArea><wicri:noRegion>Banska Bystrica</wicri:noRegion></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation wicri:level="3"><nlm:affiliation>Second Department of Pediatrics, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Trahair, Toby" sort="Trahair, Toby" uniqKey="Trahair T" first="Toby" last="Trahair">Toby Trahair</name><affiliation wicri:level="1"><nlm:affiliation>Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Canete, Adela" sort="Canete, Adela" uniqKey="Canete A" first="Adela" last="Canete">Adela Canete</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Oncology Unit, Hospital Universitario y Politecnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Ambros, Peter F" sort="Ambros, Peter F" uniqKey="Ambros P" first="Peter F" last="Ambros">Peter F. Ambros</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute Department of Tumour Biology, Medical University, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute Department of Tumour Biology, Medical University, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Holmes, Keith" sort="Holmes, Keith" uniqKey="Holmes K" first="Keith" last="Holmes">Keith Holmes</name><affiliation wicri:level="3"><nlm:affiliation>Department Paediatric Surgery, St Georges Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department Paediatric Surgery, St Georges Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gaze, Mark" sort="Gaze, Mark" uniqKey="Gaze M" first="Mark" last="Gaze">Mark Gaze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University College Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schreier, Gunter" sort="Schreier, Gunter" uniqKey="Schreier G" first="Günter" last="Schreier">Günter Schreier</name><affiliation wicri:level="1"><nlm:affiliation>Center for Health and Bioresources, AIT Austrian Institute of Technology, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Center for Health and Bioresources, AIT Austrian Institute of Technology, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Garaventa, Alberto" sort="Garaventa, Alberto" uniqKey="Garaventa A" first="Alberto" last="Garaventa">Alberto Garaventa</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Unit, Istituto Giannina Gaslini, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Unit, Istituto Giannina Gaslini, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Vassal, Gilles" sort="Vassal, Gilles" uniqKey="Vassal G" first="Gilles" last="Vassal">Gilles Vassal</name><affiliation wicri:level="3"><nlm:affiliation>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michon, Jean" sort="Michon, Jean" uniqKey="Michon J" first="Jean" last="Michon">Jean Michon</name><affiliation wicri:level="3"><nlm:affiliation>Children, Adolescent and Young Adults Department, Institut Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children, Adolescent and Young Adults Department, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Valteau Couanet, Dominique" sort="Valteau Couanet, Dominique" uniqKey="Valteau Couanet D" first="Dominique" last="Valteau-Couanet">Dominique Valteau-Couanet</name><affiliation wicri:level="3"><nlm:affiliation>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Bone Neoplasms (drug therapy)</term><term>Bone Neoplasms (secondary)</term><term>Busulfan (administration & dosage)</term><term>Carboplatin (administration & dosage)</term><term>Child</term><term>Child, Preschool</term><term>Etoposide (administration & dosage)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>International Agencies</term><term>Lymphatic Metastasis</term><term>Male</term><term>Melphalan (administration & dosage)</term><term>Neoplasm Staging</term><term>Neuroblastoma (drug therapy)</term><term>Neuroblastoma (pathology)</term><term>Prognosis</term><term>Survival Rate</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Agences internationales</term><term>Busulfan (administration et posologie)</term><term>Carboplatine (administration et posologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Melphalan (administration et posologie)</term><term>Mâle</term><term>Métastase lymphatique</term><term>Neuroblastome (anatomopathologie)</term><term>Neuroblastome (traitement médicamenteux)</term><term>Nourrisson</term><term>Pronostic</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Stade de la tumeur</term><term>Taux de survie</term><term>Tumeurs osseuses (secondaire)</term><term>Tumeurs osseuses (traitement médicamenteux)</term><term>Étoposide (administration et posologie)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Busulfan</term><term>Carboplatin</term><term>Etoposide</term><term>Melphalan</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Busulfan</term><term>Carboplatine</term><term>Melphalan</term><term>Étoposide</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Neuroblastome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bone Neoplasms</term><term>Neuroblastoma</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neuroblastoma</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Neuroblastome</term><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>International Agencies</term><term>Lymphatic Metastasis</term><term>Male</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Survival Rate</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Agences internationales</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Métastase lymphatique</term><term>Nourrisson</term><term>Pronostic</term><term>Stade de la tumeur</term><term>Taux de survie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however, which regimen has the greatest patient benefit has not been established. We aimed to assess event-free survival after high-dose chemotherapy with busulfan and melphalan compared with carboplatin, etoposide, and melphalan.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Hongrie</li><li>Israël</li><li>Italie</li><li>Norvège</li><li>Pologne</li><li>Portugal</li><li>Royaume-Uni</li><li>République tchèque</li><li>Slovaquie</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Bohême centrale</li><li>Canton de Vaud</li><li>Grand Londres</li><li>Hongrie centrale</li><li>Lombardie</li><li>Svealand</li><li>Vienne (Autriche)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Athènes</li><li>Budapest</li><li>Lausanne</li><li>Londres</li><li>Milan</li><li>Oslo</li><li>Paris</li><li>Prague</li><li>Stockholm</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ladenstein, Ruth" sort="Ladenstein, Ruth" uniqKey="Ladenstein R" first="Ruth" last="Ladenstein">Ruth Ladenstein</name></region><name sortKey="Ambros, Peter F" sort="Ambros, Peter F" uniqKey="Ambros P" first="Peter F" last="Ambros">Peter F. Ambros</name><name sortKey="Potschger, Ulrike" sort="Potschger, Ulrike" uniqKey="Potschger U" first="Ulrike" last="Pötschger">Ulrike Pötschger</name><name sortKey="Schreier, Gunter" sort="Schreier, Gunter" uniqKey="Schreier G" first="Günter" last="Schreier">Günter Schreier</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Pearson, Andrew D J" sort="Pearson, Andrew D J" uniqKey="Pearson A" first="Andrew D J" last="Pearson">Andrew D J. Pearson</name></noRegion><name sortKey="Brock, Penelope" sort="Brock, Penelope" uniqKey="Brock P" first="Penelope" last="Brock">Penelope Brock</name><name sortKey="Gaze, Mark" sort="Gaze, Mark" uniqKey="Gaze M" first="Mark" last="Gaze">Mark Gaze</name><name sortKey="Holmes, Keith" sort="Holmes, Keith" uniqKey="Holmes K" first="Keith" last="Holmes">Keith Holmes</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Luksch, Roberto" sort="Luksch, Roberto" uniqKey="Luksch R" first="Roberto" last="Luksch">Roberto Luksch</name></region><name sortKey="Garaventa, Alberto" sort="Garaventa, Alberto" uniqKey="Garaventa A" first="Alberto" last="Garaventa">Alberto Garaventa</name></country><country name="Espagne"><noRegion><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name></noRegion><name sortKey="Canete, Adela" sort="Canete, Adela" uniqKey="Canete A" first="Adela" last="Canete">Adela Canete</name></country><country name="Israël"><noRegion><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Papadakis, Vassilios" sort="Papadakis, Vassilios" uniqKey="Papadakis V" first="Vassilios" last="Papadakis">Vassilios Papadakis</name></region></country><country name="Belgique"><noRegion><name sortKey="Laureys, Genevieve" sort="Laureys, Genevieve" uniqKey="Laureys G" first="Geneviève" last="Laureys">Geneviève Laureys</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Malis, Josef" sort="Malis, Josef" uniqKey="Malis J" first="Josef" last="Malis">Josef Malis</name></region></country><country name="Pologne"><noRegion><name sortKey="Balwierz, Walentyna" sort="Balwierz, Walentyna" uniqKey="Balwierz W" first="Walentyna" last="Balwierz">Walentyna Balwierz</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Ruud, Ellen" sort="Ruud, Ellen" uniqKey="Ruud E" first="Ellen" last="Ruud">Ellen Ruud</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Kogner, Per" sort="Kogner, Per" uniqKey="Kogner P" first="Per" last="Kogner">Per Kogner</name></region></country><country name="Danemark"><noRegion><name sortKey="Schroeder, Henrik" sort="Schroeder, Henrik" uniqKey="Schroeder H" first="Henrik" last="Schroeder">Henrik Schroeder</name></noRegion></country><country name="Portugal"><noRegion><name sortKey="De Lacerda, Ana Forjaz" sort="De Lacerda, Ana Forjaz" uniqKey="De Lacerda A" first="Ana Forjaz" last="De Lacerda">Ana Forjaz De Lacerda</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Beck Popovic, Maja" sort="Beck Popovic, Maja" uniqKey="Beck Popovic M" first="Maja" last="Beck-Popovic">Maja Beck-Popovic</name></region></country><country name="Slovaquie"><noRegion><name sortKey="Bician, Pavel" sort="Bician, Pavel" uniqKey="Bician P" first="Pavel" last="Bician">Pavel Bician</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name></region></country><country name="Australie"><noRegion><name sortKey="Trahair, Toby" sort="Trahair, Toby" uniqKey="Trahair T" first="Toby" last="Trahair">Toby Trahair</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Vassal, Gilles" sort="Vassal, Gilles" uniqKey="Vassal G" first="Gilles" last="Vassal">Gilles Vassal</name></region><name sortKey="Michon, Jean" sort="Michon, Jean" uniqKey="Michon J" first="Jean" last="Michon">Jean Michon</name><name sortKey="Valteau Couanet, Dominique" sort="Valteau Couanet, Dominique" uniqKey="Valteau Couanet D" first="Dominique" last="Valteau-Couanet">Dominique Valteau-Couanet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.
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